HDL Function: Redefining the HDL Hypothesis for the 21 Century
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منابع مشابه
High-Density Lipoprotein Measurement Methods: From Precipitation to Nuclear Magnetic Resonance (NMR)
Introduction: Extensive research suggests a common hypothesis regarding the protective role of total high-density lipoprotein-cholesterol (HDL-C) against cardiovascular disease (CVD). This hypothesis indicates an inverse relationship between CVD and high HDL-C levels. Various mechanisms, such as reverse cholesterol transport, besides anti-inflammatory and antioxidant functions, indicate HDL-C a...
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High-density lipoprotein (HDL) is a set of particles with heterogeneous structures that have different functions due to various compounds including surface charge, size, lipid, and protein compounds. Several prospective epidemiological studies have demonstrated that there is a clear inverse relationship between serum HDL concentration and risk of coronary heart disease, despite this relationshi...
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BACKGROUND Carriers of the apolipoprotein A-I(Milano) (apoA-I(M)) mutant have very low plasma high-density lipoprotein cholesterol (HDL-C) levels but do not show any history of premature cardiovascular disease or any evidence of preclinical vascular disease. HDL is believed to prevent the development of vascular dysfunction, which may well contribute to HDL-mediated atheroprotection. Whether th...
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Several studies have shown an inverse relationship between HDL cholesterol (HDL-C) levels and the risk of cardiovascular disease. Low HDL-C levels are commonly present in subjects with diabetes, metabolic syndrome, or obesity. These observations have suggested that increasing HDL concentrations might help in decreasing the cardiovascular disease risk. However, despite initial positive results, ...
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A low level of high-density lipoprotein cholesterol (HDL-C) is an important cardiovascular risk factor, and is commonly seen in patients with type 2 diabetes mellitus. An inverse relationship between HDL-C concentration and cardiovascular risk has been consistently shown in clinical and epidemiological studies. In the well-known Framingham Heart Study, HDL-C was found to be the best predictor o...
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